In the year 2012, few French scientists found about the existence of few cannabinoid receptors on our membranes of mitochondria, which is energy-generating organelle present within our cells.
With this discovery, subsequent investigations about the role of our endocannabinoid system to regulate mitochondrial activity, that is critical for the function of our cells was understood.
Various defects in mitochondria were linked to a range of neurodegenerative, metabolic and autoimmune disorders e.g.
- Alzheimer’s
- Autism
- Cancer
- Cardiovascular/neuromuscular disease
- Diabetes
- Epilepsy
- Schizophrenia.
After obtaining various scientific data, it was found that cannabidiol, which is CBD and tetrahydrocannabinol called as THC are the 2 key components present in the cannabis plant. This will be able to affect mitochondria, directly and also indirectly.
Finally, it turns out that many of our biological pathways which involve mitochondria includes oxidative stress, energy homeostasis and neurotransmitter release are modulated by exogenous and endogenous cannabinoids.
That is how scientists could establish that CBD wholesale has the ability to regulate our pain and inflammation, and thus are used as a valuable tool for treatment of many different health conditions.
Now let us try to understand how CBD oil can impact in our cellular function, and also break down the scientific theory to explain how cannabidiol can interact with our cells.
CBD oil role in homeostasis
This term homeostasis is used to describe our state of equilibrium where our body will perform the best with various physiological processes, which is contributing to our balanced system.
A study report published during 2016 in one Pharmacology journal of Europe, that reported
any imbalance of calcium and sodium homeostasis will trigger pathophysiologic processes in our cerebral ischemia, that accelerate our neuronal brain death.
Also, further study on this is linked to the imbalance created due to the mitochondrial calcium to neurological conditions like Alzheimer’s disease.
On the mitochondria surface like NCX or sodium-calcium exchanger, CBD oil can impact the receptors.
When this receptor will get bound then it will open a channel where ions can freely pass from high concentration to low concentration. CBD oil can allow homeostasis through this process within the cell, and regulate the calcium flow through the NCX.
Finally, the CBD oil’s regulating effect on mitochondria and also its management of intracellular calcium levels could have some neuroprotective benefits.
CBD oil impact on oxidization and free radicals
Usually, oxidative phosphorylation is quite efficient, but a complicated process. Actually, the process of oxidative phosphorylation in which the energy will be created for cell via electron transportation.
Occasionally, during the process hydrogen peroxide and ionized oxygen will form and will be released into our body. Often such unstable molecules known as free radicals can damage DNA, cell membranes and protein.
Antioxidants can neutralize such free radicals, reduces oxidative stress and also risk of any long-term damage. For encouraging the cell protection, CBD oil can be a potent antioxidant, which will trigger CB2 cannabinoid receptor.
Though many other foods and consumable items are labeled as antioxidants, CBD oil is among the most promising.
Following the research report published in 1998, patent was filed on antioxidant properties of CBD for therapeutic use.
